EAACI Molecular Allergology User's Guide.
Identifieur interne : 002059 ( Main/Exploration ); précédent : 002058; suivant : 002060EAACI Molecular Allergology User's Guide.
Auteurs : P M Matricardi [Allemagne] ; J. Kleine-Tebbe [Allemagne] ; H J Hoffmann [Danemark] ; R. Valenta [Autriche] ; C. Hilger [Luxembourg (pays)] ; S. Hofmaier [Allemagne] ; R C Aalberse [Pays-Bas] ; I. Agache [Roumanie] ; R. Asero [Italie] ; B. Ballmer-Weber [Suisse] ; D. Barber [Espagne] ; K. Beyer [Allemagne] ; T. Biedermann [Allemagne] ; M B Bil [Italie] ; S. Blank [Allemagne] ; B. Bohle [Autriche] ; P P Bosshard [Suisse] ; H. Breiteneder [Autriche] ; H A Brough [Royaume-Uni] ; L. Caraballo [Colombie] ; J C Caubet [Suisse] ; R. Crameri [Suisse] ; J M Davies [Australie] ; N. Douladiris [Grèce] ; M. Ebisawa [Japon] ; P A Eigenmann [Suisse] ; M. Fernandez-Rivas [Espagne] ; F. Ferreira [Autriche] ; G. Gadermaier [Autriche] ; M. Glatz [Suisse] ; R G Hamilton [États-Unis] ; T. Hawranek [Autriche] ; P. Hellings [Pays-Bas] ; K. Hoffmann-Sommergruber [Autriche] ; T. Jakob [Allemagne] ; U. Jappe [Allemagne] ; M. Jutel [Pologne] ; S D Kamath [Australie] ; E F Knol [Pays-Bas] ; P. Korosec [Slovénie] ; A. Kuehn [Luxembourg (pays)] ; G. Lack [Royaume-Uni] ; A L Lopata [Pologne] ; M. M Kel [Finlande] ; M. Morisset [Royaume-Uni] ; V. Niederberger [Autriche] ; A H Nowak-W Grzyn [États-Unis] ; N G Papadopoulos [Royaume-Uni] ; E A Pastorello [Italie] ; G. Pauli [France] ; T. Platts-Mills [États-Unis] ; D. Posa [Allemagne] ; L K Poulsen [Danemark] ; M. Raulf [Allemagne] ; J. Sastre [Espagne] ; E. Scala [Italie] ; J M Schmid [Danemark] ; P. Schmid-Grendelmeier [Suisse] ; M. Van Hage [Suède] ; R. Van Ree [Pays-Bas] ; S. Vieths [Allemagne] ; R. Weber [États-Unis] ; M. Wickman [Suède] ; A. Muraro [Italie] ; M. Ollert [Luxembourg (pays)]Source :
- Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [ 1399-3038 ] ; 2016.
Abstract
The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.
DOI: 10.1111/pai.12563
PubMed: 27288833
Affiliations:
- Allemagne, Australie, Autriche, Colombie, Danemark, Espagne, Finlande, France, Grèce, Italie, Japon, Luxembourg (pays), Pays-Bas, Pologne, Roumanie, Royaume-Uni, Slovénie, Suisse, Suède, États-Unis
- Alsace (région administrative), Angleterre, Attique (région), Bavière, Berlin, Canton de Zurich, Colorado, Communauté de Madrid, District de Haute-Bavière, Grand Est, Grand Londres, Grand Manchester, Hollande-Septentrionale, Hovedstaden, Latium, Lombardie, Maryland, Svealand, Utrecht (province), Vienne (Autriche), Virginie, État de New York
- Amsterdam, Athènes, Berlin, Copenhague, Londres, Madrid, Manchester, Milan, Munich, Rome, Stockholm, Strasbourg, Utrecht, Vienne (Autriche), Zurich
- Université Louis-et-Maximilien de Munich, Université d'Amsterdam, Université de Manchester, Université de Zurich
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Kleine-Tebbe</name><affiliation wicri:level="3"><nlm:affiliation>Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & Kleine-Tebbe, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hoffmann, H J" sort="Hoffmann, H J" uniqKey="Hoffmann H" first="H J" last="Hoffmann">H J Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Valenta, R" sort="Valenta, R" uniqKey="Valenta R" first="R" last="Valenta">R. Valenta</name><affiliation wicri:level="3"><nlm:affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Hilger, C" sort="Hilger, C" uniqKey="Hilger C" first="C" last="Hilger">C. Hilger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette</wicri:regionArea><wicri:noRegion>Esch-sur-Alzette</wicri:noRegion></affiliation></author><author><name sortKey="Hofmaier, S" sort="Hofmaier, S" uniqKey="Hofmaier S" first="S" last="Hofmaier">S. Hofmaier</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R C" last="Aalberse">R C Aalberse</name><affiliation wicri:level="3"><nlm:affiliation>Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Sanquin Research, Department of Immunopathology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Agache, I" sort="Agache, I" uniqKey="Agache I" first="I" last="Agache">I. Agache</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov</wicri:regionArea><wicri:noRegion>Brasov</wicri:noRegion></affiliation></author><author><name sortKey="Asero, R" sort="Asero, R" uniqKey="Asero R" first="R" last="Asero">R. Asero</name><affiliation wicri:level="1"><nlm:affiliation>Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano</wicri:regionArea><wicri:noRegion>Paderno Dugnano</wicri:noRegion></affiliation></author><author><name sortKey="Ballmer Weber, B" sort="Ballmer Weber, B" uniqKey="Ballmer Weber B" first="B" last="Ballmer-Weber">B. Ballmer-Weber</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barber, D" sort="Barber, D" uniqKey="Barber D" first="D" last="Barber">D. Barber</name><affiliation wicri:level="3"><nlm:affiliation>IMMA-School of Medicine, University CEU San Pablo, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>IMMA-School of Medicine, University CEU San Pablo, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Beyer, K" sort="Beyer, K" uniqKey="Beyer K" first="K" last="Beyer">K. Beyer</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Biedermann, T" sort="Biedermann, T" uniqKey="Biedermann T" first="T" last="Biedermann">T. Biedermann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, Technical University Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, Technical University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Bil, M B" sort="Bil, M B" uniqKey="Bil M" first="M B" last="Bil">M B Bil</name><affiliation wicri:level="1"><nlm:affiliation>Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Blank, S" sort="Blank, S" uniqKey="Blank S" first="S" last="Blank">S. Blank</name><affiliation wicri:level="4"><nlm:affiliation>Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Bohle, B" sort="Bohle, B" uniqKey="Bohle B" first="B" last="Bohle">B. Bohle</name><affiliation wicri:level="3"><nlm:affiliation>Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Bosshard, P P" sort="Bosshard, P P" uniqKey="Bosshard P" first="P P" last="Bosshard">P P Bosshard</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Breiteneder, H" sort="Breiteneder, H" uniqKey="Breiteneder H" first="H" last="Breiteneder">H. Breiteneder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Brough, H A" sort="Brough, H A" uniqKey="Brough H" first="H A" last="Brough">H A Brough</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Caraballo, L" sort="Caraballo, L" uniqKey="Caraballo L" first="L" last="Caraballo">L. Caraballo</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Institute for Immunological Research, The University of Cartagena, Cartagena de Indias</wicri:regionArea><wicri:noRegion>Cartagena de Indias</wicri:noRegion></affiliation></author><author><name sortKey="Caubet, J C" sort="Caubet, J C" uniqKey="Caubet J" first="J C" last="Caubet">J C Caubet</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Crameri, R" sort="Crameri, R" uniqKey="Crameri R" first="R" last="Crameri">R. Crameri</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Davies, J M" sort="Davies, J M" uniqKey="Davies J" first="J M" last="Davies">J M Davies</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld</wicri:regionArea><wicri:noRegion>Qld</wicri:noRegion></affiliation></author><author><name sortKey="Douladiris, N" sort="Douladiris, N" uniqKey="Douladiris N" first="N" last="Douladiris">N. Douladiris</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Ebisawa, M" sort="Ebisawa, M" uniqKey="Ebisawa M" first="M" last="Ebisawa">M. Ebisawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Eigenmann, P A" sort="Eigenmann, P A" uniqKey="Eigenmann P" first="P A" last="Eigenmann">P A Eigenmann</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Rivas, M" sort="Fernandez Rivas, M" uniqKey="Fernandez Rivas M" first="M" last="Fernandez-Rivas">M. Fernandez-Rivas</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ferreira, F" sort="Ferreira, F" uniqKey="Ferreira F" first="F" last="Ferreira">F. Ferreira</name><affiliation wicri:level="1"><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Gadermaier, G" sort="Gadermaier, G" uniqKey="Gadermaier G" first="G" last="Gadermaier">G. Gadermaier</name><affiliation wicri:level="1"><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Glatz, M" sort="Glatz, M" uniqKey="Glatz M" first="M" last="Glatz">M. Glatz</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Hamilton, R G" sort="Hamilton, R G" uniqKey="Hamilton R" first="R G" last="Hamilton">R G Hamilton</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hawranek, T" sort="Hawranek, T" uniqKey="Hawranek T" first="T" last="Hawranek">T. Hawranek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Dermatology, Paracelsus Private Medical University, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Hellings, P" sort="Hellings, P" uniqKey="Hellings P" first="P" last="Hellings">P. Hellings</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hoffmann Sommergruber, K" sort="Hoffmann Sommergruber, K" uniqKey="Hoffmann Sommergruber K" first="K" last="Hoffmann-Sommergruber">K. Hoffmann-Sommergruber</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Jakob, T" sort="Jakob, T" uniqKey="Jakob T" first="T" last="Jakob">T. Jakob</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Jappe, U" sort="Jappe, U" uniqKey="Jappe U" first="U" last="Jappe">U. Jappe</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel</wicri:regionArea><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion></affiliation></author><author><name sortKey="Jutel, M" sort="Jutel, M" uniqKey="Jutel M" first="M" last="Jutel">M. Jutel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław</wicri:regionArea><wicri:noRegion>Wrocław</wicri:noRegion></affiliation></author><author><name sortKey="Kamath, S D" sort="Kamath, S D" uniqKey="Kamath S" first="S D" last="Kamath">S D Kamath</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld</wicri:regionArea><wicri:noRegion>Qld</wicri:noRegion></affiliation></author><author><name sortKey="Knol, E F" sort="Knol, E F" uniqKey="Knol E" first="E F" last="Knol">E F Knol</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Korosec, P" sort="Korosec, P" uniqKey="Korosec P" first="P" last="Korosec">P. Korosec</name><affiliation wicri:level="1"><nlm:affiliation>University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>University Clinic of Respiratory and Allergic Diseases, Golnik</wicri:regionArea><wicri:noRegion>Golnik</wicri:noRegion></affiliation></author><author><name sortKey="Kuehn, A" sort="Kuehn, A" uniqKey="Kuehn A" first="A" last="Kuehn">A. Kuehn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette</wicri:regionArea><wicri:noRegion>Esch-sur-Alzette</wicri:noRegion></affiliation></author><author><name sortKey="Lack, G" sort="Lack, G" uniqKey="Lack G" first="G" last="Lack">G. Lack</name><affiliation wicri:level="3"><nlm:affiliation>King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lopata, A L" sort="Lopata, A L" uniqKey="Lopata A" first="A L" last="Lopata">A L Lopata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław</wicri:regionArea><wicri:noRegion>Wrocław</wicri:noRegion></affiliation></author><author><name sortKey="M Kel, M" sort="M Kel, M" uniqKey="M Kel M" first="M" last="M Kel">M. M Kel</name><affiliation wicri:level="1"><nlm:affiliation>Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Morisset, M" sort="Morisset, M" uniqKey="Morisset M" first="M" last="Morisset">M. Morisset</name><affiliation wicri:level="1"><nlm:affiliation>National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg</wicri:regionArea><wicri:noRegion>Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Niederberger, V" sort="Niederberger, V" uniqKey="Niederberger V" first="V" last="Niederberger">V. Niederberger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Otorhinolaryngology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Nowak W Grzyn, A H" sort="Nowak W Grzyn, A H" uniqKey="Nowak W Grzyn A" first="A H" last="Nowak-W Grzyn">A H Nowak-W Grzyn</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Papadopoulos, N G" sort="Papadopoulos, N G" uniqKey="Papadopoulos N" first="N G" last="Papadopoulos">N G Papadopoulos</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Pastorello, E A" sort="Pastorello, E A" uniqKey="Pastorello E" first="E A" last="Pastorello">E A Pastorello</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pauli, G" sort="Pauli, G" uniqKey="Pauli G" first="G" last="Pauli">G. Pauli</name><affiliation wicri:level="3"><nlm:affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Platts Mills, T" sort="Platts Mills, T" uniqKey="Platts Mills T" first="T" last="Platts-Mills">T. Platts-Mills</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Posa, D" sort="Posa, D" uniqKey="Posa D" first="D" last="Posa">D. Posa</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Poulsen, L K" sort="Poulsen, L K" uniqKey="Poulsen L" first="L K" last="Poulsen">L K Poulsen</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Allergy Clinic, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Raulf, M" sort="Raulf, M" uniqKey="Raulf M" first="M" last="Raulf">M. Raulf</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum</wicri:regionArea><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Sastre, J" sort="Sastre, J" uniqKey="Sastre J" first="J" last="Sastre">J. Sastre</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Division, Fundación Jimenez Díaz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Allergy Division, Fundación Jimenez Díaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Scala, E" sort="Scala, E" uniqKey="Scala E" first="E" last="Scala">E. Scala</name><affiliation wicri:level="3"><nlm:affiliation>Experimental Allergy Unit, IDI-IRCCS, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Experimental Allergy Unit, IDI-IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Schmid, J M" sort="Schmid, J M" uniqKey="Schmid J" first="J M" last="Schmid">J M Schmid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Schmid Grendelmeier, P" sort="Schmid Grendelmeier, P" uniqKey="Schmid Grendelmeier P" first="P" last="Schmid-Grendelmeier">P. Schmid-Grendelmeier</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Van Hage, M" sort="Van Hage, M" uniqKey="Van Hage M" first="M" last="Van Hage">M. Van Hage</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Van Ree, R" sort="Van Ree, R" uniqKey="Van Ree R" first="R" last="Van Ree">R. Van Ree</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Vieths, S" sort="Vieths, S" uniqKey="Vieths S" first="S" last="Vieths">S. Vieths</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Allergology, Paul-Ehrlich-Institut, Langen</wicri:regionArea><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion></affiliation></author><author><name sortKey="Weber, R" sort="Weber, R" uniqKey="Weber R" first="R" last="Weber">R. Weber</name><affiliation wicri:level="2"><nlm:affiliation>School of Medicine, University of Colorado, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, University of Colorado, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Wickman, M" sort="Wickman, M" uniqKey="Wickman M" first="M" last="Wickman">M. Wickman</name><affiliation wicri:level="3"><nlm:affiliation>Sachs' Children's Hospital, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Sachs' Children's Hospital, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Muraro, A" sort="Muraro, A" uniqKey="Muraro A" first="A" last="Muraro">A. Muraro</name><affiliation wicri:level="1"><nlm:affiliation>The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Ollert, M" sort="Ollert, M" uniqKey="Ollert M" first="M" last="Ollert">M. Ollert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette</wicri:regionArea><wicri:noRegion>Esch-sur-Alzette</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27288833</idno><idno type="pmid">27288833</idno><idno type="doi">10.1111/pai.12563</idno><idno type="wicri:Area/PubMed/Corpus">001F12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F12</idno><idno type="wicri:Area/PubMed/Curation">001E88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001E88</idno><idno type="wicri:Area/PubMed/Checkpoint">001E88</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E88</idno><idno type="wicri:Area/Ncbi/Merge">003687</idno><idno type="wicri:Area/Ncbi/Curation">003687</idno><idno type="wicri:Area/Ncbi/Checkpoint">003687</idno><idno type="wicri:Area/Main/Merge">002058</idno><idno type="wicri:Area/Main/Curation">002059</idno><idno type="wicri:Area/Main/Exploration">002059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">EAACI Molecular Allergology User's Guide.</title><author><name sortKey="Matricardi, P M" sort="Matricardi, P M" uniqKey="Matricardi P" first="P M" last="Matricardi">P M Matricardi</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kleine Tebbe, J" sort="Kleine Tebbe, J" uniqKey="Kleine Tebbe J" first="J" last="Kleine-Tebbe">J. Kleine-Tebbe</name><affiliation wicri:level="3"><nlm:affiliation>Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & Kleine-Tebbe, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hoffmann, H J" sort="Hoffmann, H J" uniqKey="Hoffmann H" first="H J" last="Hoffmann">H J Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Valenta, R" sort="Valenta, R" uniqKey="Valenta R" first="R" last="Valenta">R. Valenta</name><affiliation wicri:level="3"><nlm:affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Hilger, C" sort="Hilger, C" uniqKey="Hilger C" first="C" last="Hilger">C. Hilger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette</wicri:regionArea><wicri:noRegion>Esch-sur-Alzette</wicri:noRegion></affiliation></author><author><name sortKey="Hofmaier, S" sort="Hofmaier, S" uniqKey="Hofmaier S" first="S" last="Hofmaier">S. Hofmaier</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R C" last="Aalberse">R C Aalberse</name><affiliation wicri:level="3"><nlm:affiliation>Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Sanquin Research, Department of Immunopathology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Agache, I" sort="Agache, I" uniqKey="Agache I" first="I" last="Agache">I. Agache</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov</wicri:regionArea><wicri:noRegion>Brasov</wicri:noRegion></affiliation></author><author><name sortKey="Asero, R" sort="Asero, R" uniqKey="Asero R" first="R" last="Asero">R. Asero</name><affiliation wicri:level="1"><nlm:affiliation>Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano</wicri:regionArea><wicri:noRegion>Paderno Dugnano</wicri:noRegion></affiliation></author><author><name sortKey="Ballmer Weber, B" sort="Ballmer Weber, B" uniqKey="Ballmer Weber B" first="B" last="Ballmer-Weber">B. Ballmer-Weber</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Barber, D" sort="Barber, D" uniqKey="Barber D" first="D" last="Barber">D. Barber</name><affiliation wicri:level="3"><nlm:affiliation>IMMA-School of Medicine, University CEU San Pablo, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>IMMA-School of Medicine, University CEU San Pablo, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Beyer, K" sort="Beyer, K" uniqKey="Beyer K" first="K" last="Beyer">K. Beyer</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Biedermann, T" sort="Biedermann, T" uniqKey="Biedermann T" first="T" last="Biedermann">T. Biedermann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, Technical University Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, Technical University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Bil, M B" sort="Bil, M B" uniqKey="Bil M" first="M B" last="Bil">M B Bil</name><affiliation wicri:level="1"><nlm:affiliation>Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Blank, S" sort="Blank, S" uniqKey="Blank S" first="S" last="Blank">S. Blank</name><affiliation wicri:level="4"><nlm:affiliation>Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Bohle, B" sort="Bohle, B" uniqKey="Bohle B" first="B" last="Bohle">B. Bohle</name><affiliation wicri:level="3"><nlm:affiliation>Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Bosshard, P P" sort="Bosshard, P P" uniqKey="Bosshard P" first="P P" last="Bosshard">P P Bosshard</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Breiteneder, H" sort="Breiteneder, H" uniqKey="Breiteneder H" first="H" last="Breiteneder">H. Breiteneder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Brough, H A" sort="Brough, H A" uniqKey="Brough H" first="H A" last="Brough">H A Brough</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Caraballo, L" sort="Caraballo, L" uniqKey="Caraballo L" first="L" last="Caraballo">L. Caraballo</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Institute for Immunological Research, The University of Cartagena, Cartagena de Indias</wicri:regionArea><wicri:noRegion>Cartagena de Indias</wicri:noRegion></affiliation></author><author><name sortKey="Caubet, J C" sort="Caubet, J C" uniqKey="Caubet J" first="J C" last="Caubet">J C Caubet</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Crameri, R" sort="Crameri, R" uniqKey="Crameri R" first="R" last="Crameri">R. Crameri</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Davies, J M" sort="Davies, J M" uniqKey="Davies J" first="J M" last="Davies">J M Davies</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld</wicri:regionArea><wicri:noRegion>Qld</wicri:noRegion></affiliation></author><author><name sortKey="Douladiris, N" sort="Douladiris, N" uniqKey="Douladiris N" first="N" last="Douladiris">N. Douladiris</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Ebisawa, M" sort="Ebisawa, M" uniqKey="Ebisawa M" first="M" last="Ebisawa">M. Ebisawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Eigenmann, P A" sort="Eigenmann, P A" uniqKey="Eigenmann P" first="P A" last="Eigenmann">P A Eigenmann</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Rivas, M" sort="Fernandez Rivas, M" uniqKey="Fernandez Rivas M" first="M" last="Fernandez-Rivas">M. Fernandez-Rivas</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ferreira, F" sort="Ferreira, F" uniqKey="Ferreira F" first="F" last="Ferreira">F. Ferreira</name><affiliation wicri:level="1"><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Gadermaier, G" sort="Gadermaier, G" uniqKey="Gadermaier G" first="G" last="Gadermaier">G. Gadermaier</name><affiliation wicri:level="1"><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Glatz, M" sort="Glatz, M" uniqKey="Glatz M" first="M" last="Glatz">M. Glatz</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Hamilton, R G" sort="Hamilton, R G" uniqKey="Hamilton R" first="R G" last="Hamilton">R G Hamilton</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hawranek, T" sort="Hawranek, T" uniqKey="Hawranek T" first="T" last="Hawranek">T. Hawranek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Dermatology, Paracelsus Private Medical University, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Hellings, P" sort="Hellings, P" uniqKey="Hellings P" first="P" last="Hellings">P. Hellings</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hoffmann Sommergruber, K" sort="Hoffmann Sommergruber, K" uniqKey="Hoffmann Sommergruber K" first="K" last="Hoffmann-Sommergruber">K. Hoffmann-Sommergruber</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Jakob, T" sort="Jakob, T" uniqKey="Jakob T" first="T" last="Jakob">T. Jakob</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Jappe, U" sort="Jappe, U" uniqKey="Jappe U" first="U" last="Jappe">U. Jappe</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel</wicri:regionArea><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion></affiliation></author><author><name sortKey="Jutel, M" sort="Jutel, M" uniqKey="Jutel M" first="M" last="Jutel">M. Jutel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław</wicri:regionArea><wicri:noRegion>Wrocław</wicri:noRegion></affiliation></author><author><name sortKey="Kamath, S D" sort="Kamath, S D" uniqKey="Kamath S" first="S D" last="Kamath">S D Kamath</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld</wicri:regionArea><wicri:noRegion>Qld</wicri:noRegion></affiliation></author><author><name sortKey="Knol, E F" sort="Knol, E F" uniqKey="Knol E" first="E F" last="Knol">E F Knol</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Korosec, P" sort="Korosec, P" uniqKey="Korosec P" first="P" last="Korosec">P. Korosec</name><affiliation wicri:level="1"><nlm:affiliation>University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>University Clinic of Respiratory and Allergic Diseases, Golnik</wicri:regionArea><wicri:noRegion>Golnik</wicri:noRegion></affiliation></author><author><name sortKey="Kuehn, A" sort="Kuehn, A" uniqKey="Kuehn A" first="A" last="Kuehn">A. Kuehn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette</wicri:regionArea><wicri:noRegion>Esch-sur-Alzette</wicri:noRegion></affiliation></author><author><name sortKey="Lack, G" sort="Lack, G" uniqKey="Lack G" first="G" last="Lack">G. Lack</name><affiliation wicri:level="3"><nlm:affiliation>King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lopata, A L" sort="Lopata, A L" uniqKey="Lopata A" first="A L" last="Lopata">A L Lopata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław</wicri:regionArea><wicri:noRegion>Wrocław</wicri:noRegion></affiliation></author><author><name sortKey="M Kel, M" sort="M Kel, M" uniqKey="M Kel M" first="M" last="M Kel">M. M Kel</name><affiliation wicri:level="1"><nlm:affiliation>Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Morisset, M" sort="Morisset, M" uniqKey="Morisset M" first="M" last="Morisset">M. Morisset</name><affiliation wicri:level="1"><nlm:affiliation>National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg</wicri:regionArea><wicri:noRegion>Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Niederberger, V" sort="Niederberger, V" uniqKey="Niederberger V" first="V" last="Niederberger">V. Niederberger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Otorhinolaryngology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Nowak W Grzyn, A H" sort="Nowak W Grzyn, A H" uniqKey="Nowak W Grzyn A" first="A H" last="Nowak-W Grzyn">A H Nowak-W Grzyn</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Papadopoulos, N G" sort="Papadopoulos, N G" uniqKey="Papadopoulos N" first="N G" last="Papadopoulos">N G Papadopoulos</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Pastorello, E A" sort="Pastorello, E A" uniqKey="Pastorello E" first="E A" last="Pastorello">E A Pastorello</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pauli, G" sort="Pauli, G" uniqKey="Pauli G" first="G" last="Pauli">G. Pauli</name><affiliation wicri:level="3"><nlm:affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Platts Mills, T" sort="Platts Mills, T" uniqKey="Platts Mills T" first="T" last="Platts-Mills">T. Platts-Mills</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Posa, D" sort="Posa, D" uniqKey="Posa D" first="D" last="Posa">D. Posa</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Poulsen, L K" sort="Poulsen, L K" uniqKey="Poulsen L" first="L K" last="Poulsen">L K Poulsen</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Allergy Clinic, Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Raulf, M" sort="Raulf, M" uniqKey="Raulf M" first="M" last="Raulf">M. Raulf</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum</wicri:regionArea><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Sastre, J" sort="Sastre, J" uniqKey="Sastre J" first="J" last="Sastre">J. Sastre</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Division, Fundación Jimenez Díaz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Allergy Division, Fundación Jimenez Díaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Scala, E" sort="Scala, E" uniqKey="Scala E" first="E" last="Scala">E. Scala</name><affiliation wicri:level="3"><nlm:affiliation>Experimental Allergy Unit, IDI-IRCCS, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Experimental Allergy Unit, IDI-IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Schmid, J M" sort="Schmid, J M" uniqKey="Schmid J" first="J M" last="Schmid">J M Schmid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Schmid Grendelmeier, P" sort="Schmid Grendelmeier, P" uniqKey="Schmid Grendelmeier P" first="P" last="Schmid-Grendelmeier">P. Schmid-Grendelmeier</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Van Hage, M" sort="Van Hage, M" uniqKey="Van Hage M" first="M" last="Van Hage">M. Van Hage</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Van Ree, R" sort="Van Ree, R" uniqKey="Van Ree R" first="R" last="Van Ree">R. Van Ree</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Vieths, S" sort="Vieths, S" uniqKey="Vieths S" first="S" last="Vieths">S. Vieths</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Allergology, Paul-Ehrlich-Institut, Langen</wicri:regionArea><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion></affiliation></author><author><name sortKey="Weber, R" sort="Weber, R" uniqKey="Weber R" first="R" last="Weber">R. Weber</name><affiliation wicri:level="2"><nlm:affiliation>School of Medicine, University of Colorado, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, University of Colorado, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Wickman, M" sort="Wickman, M" uniqKey="Wickman M" first="M" last="Wickman">M. Wickman</name><affiliation wicri:level="3"><nlm:affiliation>Sachs' Children's Hospital, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Sachs' Children's Hospital, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Muraro, A" sort="Muraro, A" uniqKey="Muraro A" first="A" last="Muraro">A. Muraro</name><affiliation wicri:level="1"><nlm:affiliation>The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Ollert, M" sort="Ollert, M" uniqKey="Ollert M" first="M" last="Ollert">M. Ollert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette</wicri:regionArea><wicri:noRegion>Esch-sur-Alzette</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology</title><idno type="eISSN">1399-3038</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Colombie</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Japon</li><li>Luxembourg (pays)</li><li>Pays-Bas</li><li>Pologne</li><li>Roumanie</li><li>Royaume-Uni</li><li>Slovénie</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Angleterre</li><li>Attique (région)</li><li>Bavière</li><li>Berlin</li><li>Canton de Zurich</li><li>Colorado</li><li>Communauté de Madrid</li><li>District de Haute-Bavière</li><li>Grand Est</li><li>Grand Londres</li><li>Grand Manchester</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Latium</li><li>Lombardie</li><li>Maryland</li><li>Svealand</li><li>Utrecht (province)</li><li>Vienne (Autriche)</li><li>Virginie</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Berlin</li><li>Copenhague</li><li>Londres</li><li>Madrid</li><li>Manchester</li><li>Milan</li><li>Munich</li><li>Rome</li><li>Stockholm</li><li>Strasbourg</li><li>Utrecht</li><li>Vienne (Autriche)</li><li>Zurich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Amsterdam</li><li>Université de Manchester</li><li>Université de Zurich</li></orgName></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Matricardi, P M" sort="Matricardi, P M" uniqKey="Matricardi P" first="P M" last="Matricardi">P M Matricardi</name></region><name sortKey="Beyer, K" sort="Beyer, K" uniqKey="Beyer K" first="K" last="Beyer">K. Beyer</name><name sortKey="Biedermann, T" sort="Biedermann, T" uniqKey="Biedermann T" first="T" last="Biedermann">T. Biedermann</name><name sortKey="Blank, S" sort="Blank, S" uniqKey="Blank S" first="S" last="Blank">S. Blank</name><name sortKey="Hofmaier, S" sort="Hofmaier, S" uniqKey="Hofmaier S" first="S" last="Hofmaier">S. Hofmaier</name><name sortKey="Jakob, T" sort="Jakob, T" uniqKey="Jakob T" first="T" last="Jakob">T. Jakob</name><name sortKey="Jappe, U" sort="Jappe, U" uniqKey="Jappe U" first="U" last="Jappe">U. Jappe</name><name sortKey="Kleine Tebbe, J" sort="Kleine Tebbe, J" uniqKey="Kleine Tebbe J" first="J" last="Kleine-Tebbe">J. Kleine-Tebbe</name><name sortKey="Posa, D" sort="Posa, D" uniqKey="Posa D" first="D" last="Posa">D. Posa</name><name sortKey="Raulf, M" sort="Raulf, M" uniqKey="Raulf M" first="M" last="Raulf">M. Raulf</name><name sortKey="Vieths, S" sort="Vieths, S" uniqKey="Vieths S" first="S" last="Vieths">S. Vieths</name></country><country name="Danemark"><noRegion><name sortKey="Hoffmann, H J" sort="Hoffmann, H J" uniqKey="Hoffmann H" first="H J" last="Hoffmann">H J Hoffmann</name></noRegion><name sortKey="Poulsen, L K" sort="Poulsen, L K" uniqKey="Poulsen L" first="L K" last="Poulsen">L K Poulsen</name><name sortKey="Schmid, J M" sort="Schmid, J M" uniqKey="Schmid J" first="J M" last="Schmid">J M Schmid</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Valenta, R" sort="Valenta, R" uniqKey="Valenta R" first="R" last="Valenta">R. Valenta</name></region><name sortKey="Bohle, B" sort="Bohle, B" uniqKey="Bohle B" first="B" last="Bohle">B. Bohle</name><name sortKey="Breiteneder, H" sort="Breiteneder, H" uniqKey="Breiteneder H" first="H" last="Breiteneder">H. Breiteneder</name><name sortKey="Ferreira, F" sort="Ferreira, F" uniqKey="Ferreira F" first="F" last="Ferreira">F. Ferreira</name><name sortKey="Gadermaier, G" sort="Gadermaier, G" uniqKey="Gadermaier G" first="G" last="Gadermaier">G. Gadermaier</name><name sortKey="Hawranek, T" sort="Hawranek, T" uniqKey="Hawranek T" first="T" last="Hawranek">T. Hawranek</name><name sortKey="Hoffmann Sommergruber, K" sort="Hoffmann Sommergruber, K" uniqKey="Hoffmann Sommergruber K" first="K" last="Hoffmann-Sommergruber">K. Hoffmann-Sommergruber</name><name sortKey="Niederberger, V" sort="Niederberger, V" uniqKey="Niederberger V" first="V" last="Niederberger">V. Niederberger</name></country><country name="Luxembourg (pays)"><noRegion><name sortKey="Hilger, C" sort="Hilger, C" uniqKey="Hilger C" first="C" last="Hilger">C. Hilger</name></noRegion><name sortKey="Kuehn, A" sort="Kuehn, A" uniqKey="Kuehn A" first="A" last="Kuehn">A. Kuehn</name><name sortKey="Ollert, M" sort="Ollert, M" uniqKey="Ollert M" first="M" last="Ollert">M. Ollert</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R C" last="Aalberse">R C Aalberse</name></region><name sortKey="Hellings, P" sort="Hellings, P" uniqKey="Hellings P" first="P" last="Hellings">P. Hellings</name><name sortKey="Knol, E F" sort="Knol, E F" uniqKey="Knol E" first="E F" last="Knol">E F Knol</name><name sortKey="Van Ree, R" sort="Van Ree, R" uniqKey="Van Ree R" first="R" last="Van Ree">R. Van Ree</name></country><country name="Roumanie"><noRegion><name sortKey="Agache, I" sort="Agache, I" uniqKey="Agache I" first="I" last="Agache">I. Agache</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Asero, R" sort="Asero, R" uniqKey="Asero R" first="R" last="Asero">R. 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Crameri</name><name sortKey="Eigenmann, P A" sort="Eigenmann, P A" uniqKey="Eigenmann P" first="P A" last="Eigenmann">P A Eigenmann</name><name sortKey="Glatz, M" sort="Glatz, M" uniqKey="Glatz M" first="M" last="Glatz">M. Glatz</name><name sortKey="Schmid Grendelmeier, P" sort="Schmid Grendelmeier, P" uniqKey="Schmid Grendelmeier P" first="P" last="Schmid-Grendelmeier">P. Schmid-Grendelmeier</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Barber, D" sort="Barber, D" uniqKey="Barber D" first="D" last="Barber">D. Barber</name></region><name sortKey="Fernandez Rivas, M" sort="Fernandez Rivas, M" uniqKey="Fernandez Rivas M" first="M" last="Fernandez-Rivas">M. Fernandez-Rivas</name><name sortKey="Sastre, J" sort="Sastre, J" uniqKey="Sastre J" first="J" last="Sastre">J. 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Korosec</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="M Kel, M" sort="M Kel, M" uniqKey="M Kel M" first="M" last="M Kel">M. M Kel</name></noRegion></country><country name="France"><region name="Grand Est"><name sortKey="Pauli, G" sort="Pauli, G" uniqKey="Pauli G" first="G" last="Pauli">G. Pauli</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Van Hage, M" sort="Van Hage, M" uniqKey="Van Hage M" first="M" last="Van Hage">M. Van Hage</name></region><name sortKey="Wickman, M" sort="Wickman, M" uniqKey="Wickman M" first="M" last="Wickman">M. Wickman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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